Autor: |
Yiran Wang, Caixia Jin, Haibin Tian, Jingying Xu, Jie Chen, Shuqin Hu, Qian Li, Lixia Lu, Qingjian Ou, Guo-tong Xu, Hongping Cui |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Experimental Eye Research. 219:108939 |
ISSN: |
0014-4835 |
Popis: |
Corneal endothelial cells (CECs) play a major role in the maintenance of stromal hydration via the barrier and pump function for clear vision. Adult CECs cannot regenerate after injury. CECs cultured in vitro can undergo mitosis but may undergo corneal endothelial-to-mesenchymal transition (EnMT) and lose their endothelial characteristics. In this study, we examined the effects of CHIR99021 on transforming growth factor beta-1(TGFβ1)-induced EnMT in human CECs (hCECs) lines. CHIR99021 kept hCECs in the hexagonal shape and could downregulate the EnMT markers alpha-smooth muscle actin (α-SMA) and fibronectin (FN1), meanwhile maintained the hCECs function markers Na |
Databáze: |
OpenAIRE |
Externí odkaz: |
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