Characteristics of depressive patients according to family history of affective illness: Findings from a French national cohort
| Autor: | J.-M. Azorin, Eric Fakra, Raoul Belzeaux, E.G. Hantouche, Marc Adida |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder Generalized anxiety disorder media_common.quotation_subject Comorbidity Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders medicine Humans Bipolar disorder Age of Onset Psychiatry media_common Family Health Depressive Disorder Major Middle Aged medicine.disease 030227 psychiatry Psychiatry and Mental health Clinical Psychology Mental Health Mood Anorexia nervosa (differential diagnoses) Female Temperament France medicine.symptom Age of onset Psychology Mania 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of Affective Disorders. 198:15-22 |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2016.03.033 |
| Popis: | Background Literature is scarce about the characteristics of mood disorder patients with a family history (FH) of affective illness. The aim of the current study was to compare the prominent features of depressive patients with a FH of mania (FHM), those of depressive patients with a FH of depression (FHD), and those of depressive patients with no FH of affective illness (FHO). Methods As part of the EPIDEP National Multisite French Study of 493 consecutive DSM-IV major depressive patients evaluated in at least two semi-structured interviews 1 month apart, 45 (9.1%) were classified as FHM, 210 (42.6%) as FHD, and 238 (48.3%) as FHO. Results The main characteristics of FHM patients were a cyclothymic temperament, the presence of mixed features and diurnal variations of mood during depression, early sexual behaviour, a high number of mood episodes and hypomanic switches, high rates of suicide attempts and rapid cycling; diagnosis of bipolar disorder was more frequent in this group as well as comorbid obsessive compulsive disorder, posttraumatic stress disorder, bulimia, attention deficit/hyperactivity disorder and impulse control disorders. The FHD patients had more depressive temperament, generalized anxiety disorder, and anorexia nervosa. Compared to FHO, FHM and FHD showed an earlier age at onset, more comorbid anxiety disorders, as well as more psychotic features. Limitations The following are the limitations of this study: retrospective design, recall bias, and preferential enrolment of bipolar patients with a depressive predominant polarity. Conclusions In light of genetic studies conducted in affective disorder patients, our findings may support the hypothesis of genetic risks factors common to affective disorders and dimensions of temperament, that may extend to comorbid conditions specifically associated with bipolar or unipolar illness. |
| Databáze: | OpenAIRE |
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