A meta-analysis of the effects of aging on motor cortex neurophysiology assessed by transcranial magnetic stimulation
| Autor: | Faranak Farzan, Zafiris J. Daskalakis, Tarek K. Rajji, Benoit H. Mulsant, Apoorva Bhandari, Natasha Radhu, Daniel M. Blumberger |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine Aging Adolescent medicine.medical_treatment Electromyography Article Young Adult 03 medical and health sciences 0302 clinical medicine Physiology (medical) Neuroplasticity medicine Humans Long-term depression Aged Aged 80 and over Neuronal Plasticity medicine.diagnostic_test Interstimulus interval Age Factors Motor Cortex Neural Inhibition Human brain Middle Aged Evoked Potentials Motor Transcranial Magnetic Stimulation Sensory Systems Transcranial magnetic stimulation 030104 developmental biology medicine.anatomical_structure Neurology Silent period Neurology (clinical) Psychology Neuroscience 030217 neurology & neurosurgery Motor cortex |
| Zdroj: | Clinical Neurophysiology. 127:2834-2845 |
| ISSN: | 1388-2457 |
| DOI: | 10.1016/j.clinph.2016.05.363 |
| Popis: | Transcranial magnetic stimulation (TMS) is a non-invasive tool used for studying cortical excitability and plasticity in the human brain. This review aims to quantitatively synthesize the literature on age-related differences in cortical excitability and plasticity, examined by TMS.A literature search was conducted using MEDLINE, Embase, and PsycINFO from 1980 to December 2015. We extracted studies with healthy old (50-89years) versus young (16-49years) individuals that utilized the following TMS measures: resting motor threshold (RMT), short-interval cortical inhibition (SICI), short-latency afferent inhibition (SAI), cortical silent period (CSP), intracortical facilitation (ICF), and paired associative stimulation (PAS).We found a significant increase in RMT (g=0.414, 95% confidence interval (CI) [0.284, 0.544], p0.001), a significant decrease in SAI (g=0.778, 95% CI [0.478, 1.078], p0.001), and a trending decrease in LTP-like plasticity (g=-0.528, 95% CI [-1.157, 0.100] p0.1) with age.Our findings suggest an age-dependent reduction in cortical excitability and sensorimotor integration within the human motor cortex.Alterations in the ability to regulate cortical excitability, sensorimotor integration and plasticity may underlie several age-related motor deficits. |
| Databáze: | OpenAIRE |
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