Normal gastric inhibitory polypeptide response to oral glucose in hypothyroidism
| Autor: | Edwin K. Silverman, K M M Shakir, James H. Hays, B B Potter |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Blood Glucose Male endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Gastric Inhibitory Polypeptide Endocrinology Gastric inhibitory polypeptide Hypothyroidism Internal medicine Insulin Secretion medicine Humans Insulin Euthyroid Glucose tolerance test Gastric emptying medicine.diagnostic_test business.industry Thyroid Glucose Tolerance Test Middle Aged Glucose medicine.anatomical_structure Gastrointestinal hormone Thyroidectomy business hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Journal of Endocrinology. 140:309-312 |
| ISSN: | 1479-6805 0022-0795 |
| DOI: | 10.1677/joe.0.1400309 |
| Popis: | Although the action of gastric inhibitory polypeptide (GIP) on the β cells of the pancreas is well documented, the effect of this hormone on insulin secretion in patients who are hypothyroid has not been studied. Hypothyroid patients demonstrate increased serum immunoreactive insulin levels in response to oral glucose when compared with euthyroid subjects. We postulated that a delayed and exaggerated response of GIP could account for the hyperinsulinaemic response. Nine thyroidectomized patients (aged 44·9 ± 3·6 years) who were otherwise healthy but undergoing re-evaluation for recurrence of thyroid carcinoma, were given a 75 g oral glucose tolerance test (OGTT). These subjects were studied 6 weeks after thyroid hormone replacement had been stopped and while on hormone treatment. The serum glucose and plasma GIP responses to oral glucose were similar in the euthyroid and hypothyroid states. The serum insulin response as well as the areas under the curve for insulin following OGTT were significantly elevated (P Journal of Endocrinology (1994) 140, 309–312 |
| Databáze: | OpenAIRE |
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