Nucleophilic substitution reaction on the nitrogen of indole nucleus: Formation of 1-(indol-3-yl)indoles upon reaction of 1-hydroxyindoles with indole in formic acid
| Autor: | Masanori Somei, Yoshitomo Saga, Toshikatsu Hayashi, Fumio Yamada, Aya Goto |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Indole test Formic acid 1 (indol 3 yl)indole derivative Organic Chemistry chemistry.chemical_element Nitrogen 1 hydroxyindole derivative nitrogen Analytical Chemistry chemistry.chemical_compound SN1 reaction medicine.anatomical_structure chemistry Nucleophilic substitution medicine Organic chemistry SN2 reaction indole derivative Nucleus |
| Zdroj: | Heterocycles. 55(3):457-460 |
| Popis: | 金沢大学大学院自然科学研究科生理活性物質科学 金沢大学薬学部 1-(Indol-3-yl)indoles are obtained in excellent to good yields by the reaction of 1-hydroxyindoles with indole in 85% formic acid. Their structures are determined by X-Ray crystallographic analysis and chemical correlations. The unprecidented SN2 mechanism on the indole nitrogen is proposed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|