Pathogen-Mediated Inhibition of Anorexia Promotes Host Survival and Transmission
| Autor: | Carolyn O’Connor, Daniela Michel, Sheila Rao, Janelle S. Ayres, Alexandria M. Palaferri Schieber, Mathias Leblanc |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Salmonella typhimurium
0301 basic medicine Inflammasomes Interleukin-1beta Virulence Anorexia Biology General Biochemistry Genetics and Molecular Biology Microbiology Mice 03 medical and health sciences 0302 clinical medicine Bacterial Proteins Neural Pathways medicine Animals Humans Specific Pathogen Free Organism Pathogen Transmission (medicine) Host (biology) Effector digestive oral and skin physiology Inflammasome Specific Pathogen-Free Organisms Mice Inbred C57BL 030104 developmental biology Host-Pathogen Interactions Salmonella Infections Immunology medicine.symptom 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cell. 168:503-516.e12 |
| ISSN: | 0092-8674 |
| Popis: | Sickness-induced anorexia is a conserved behavior induced during infections. Here, we report that an intestinal pathogen, Salmonella Typhimurium, inhibits anorexia by manipulating the gut-brain axis. Inhibition of inflammasome activation by the S. Typhimurium effector, SlrP, prevented anorexia caused by IL-1β-mediated signaling to the hypothalamus via the vagus nerve. Rather than compromising host defenses, pathogen-mediated inhibition of anorexia increased host survival. SlrP-mediated inhibition of anorexia prevented invasion and systemic infection by wild-type S. Typhimurium, reducing virulence while increasing transmission to new hosts, suggesting that there are trade-offs between transmission and virulence. These results clarify the complex and contextual role of anorexia in host-pathogen interactions and suggest that microbes have evolved mechanisms to modulate sickness-induced behaviors to promote health of their host and their transmission at the expense of virulence. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|