The molecular mechanisms mediating mammalian fertilization
| Autor: | Hanisha Bhakta, Matteo A. Avella, Fares H. Refai |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Genetically modified mouse
Male Sperm binding Biology Models Biological 03 medical and health sciences 0302 clinical medicine Human fertilization Acrosome exocytosis medicine Humans Zona pellucida Molecular Biology Zona Pellucida 030304 developmental biology Sperm-Ovum Interactions 0303 health sciences 030219 obstetrics & reproductive medicine Zygote Cell Membrane Polyspermy Sperm Spermatozoa Cell biology medicine.anatomical_structure Fertilization embryonic structures Female Developmental Biology |
| Zdroj: | Development (Cambridge, England). 146(15) |
| ISSN: | 1477-9129 |
| Popis: | Fertilization is a key biological process in which the egg and sperm must recognize one another and fuse to form a zygote. Although the process is a continuum, mammalian fertilization has been studied as a sequence of steps: sperm bind and penetrate through the zona pellucida of the egg, adhere to the egg plasma membrane and finally fuse with the egg. Following fusion, effective blocks to polyspermy ensure monospermic fertilization. Here, we review how recent advances obtained using genetically modified mouse lines bring new insights into the molecular mechanisms regulating mammalian fertilization. We discuss models for these processes and we include studies showing that these mechanisms may be conserved across different mammalian species. |
| Databáze: | OpenAIRE |
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