Contact dermatitis due to nickel allergy in patients suffering from non-celiac wheat sensitivity
| Autor: | Liana Bosco, Rosario Iacobucci, Francesca Cavataio, Alberto D'Alcamo, Antonio Carroccio, Maurizio Soresi, Giuseppe Iacono, Francesca Fayer, Pasquale Mansueto, Laura Di Stefano, Francesco La Blasca, A. Arini, Girolamo Geraci |
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| Přispěvatelé: | D'Alcamo, A., Mansueto, P., Soresi, M., Iacobucci, R., La Blasca, F., Geraci, G., Cavataio, F., Fayer, F., Arini, A., DI STEFANO, L., Iacono, G., Bosco, L., Carroccio, A. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine Nickel allergy medicine.medical_specialty Letter Settore MED/09 - Medicina Interna Non-celiac wheat sensitivity non-celiac wheat insensitivity Wheat Hypersensitivity Article cutaneous symptoms 03 medical and health sciences 0302 clinical medicine Double-Blind Method Nickel Hypersensitivity medicine Cutaneous symptom Humans Ingestion In patient Prospective Studies Prospective cohort study systemic nickel allergy syndrome Triticum Irritable bowel syndrome Nutrition and Dietetics business.industry Case-control study Patch test non‐celiac wheat sensitivity nickel allergy irritable bowel syndrome Cutaneous symptoms Food Science Patch Tests medicine.disease intradermal testing Dermatology Surgery non-celiac wheat sensitivity 030104 developmental biology Case-Control Studies Dermatitis Allergic Contact Female 030211 gastroenterology & hepatology business Contact dermatitis |
| Zdroj: | Nutrients Nutrients; Volume 9; Issue 2; Pages: 103 Nutrients, 9(2):103 |
| Popis: | Background: Non‐celiac wheat sensitivity (NCWS) is a new clinical entity in the world of gluten‐related diseases. Nickel, the most frequent cause of contact allergy, can be found in wheat and results in systemic nickel allergy syndrome and mimics irritable bowel syndrome (IBS). Objective: To evaluate the frequency of contact dermatitis due to nickel allergy in NCWS patients diagnosed by a double‐blind placebo‐controlled(DBPC)challenge,and to identify the characteristics of NCWS patients with nickel allergy. Methods: We performed a prospective study of 60 patients (54 females, 6 males; mean age 34.1 ± 8.1 years) diagnosed with NCWS from December 2014 to November 2016; 80 age‐ and sex‐matched subjects with functional gastrointestina l symptoms served as controls. Patients reporting contact dermatitis related to nickel‐containing objects underwent nickel patch test (Clinicaltrials.gov registration number: NCT02750735).Results: Six out of sixty patients (10%) with NCWS suffered from contact dermatitis and nickel allergy and this frequency was statistically higher (p = 0.04)than observed in the control group(5%. The main clinical characteristic of NCWS patients with nickel allergy was a higher frequency of cutaneous symptoms after wheat ingestion compared to NCWS patients who did not suffer from nickel allergy (p < 0.0001. Conclusions: Contact dermatitis and nickel allergy are more frequent in NCWS patients than in subjects with functional gastrointestinal disorders;furthermore, these patients had a very high frequency of cutaneous manifestations after wheat ingestion. Nickel allergy should be evaluated in NCWS patients who have cutaneous manifestations after wheat ingestion. |
| Databáze: | OpenAIRE |
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