The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism
| Autor: | Anna Annunziata, Francesco Maria Fusco, Alessandro Di Minno, Margherita Ruoppolo, Giuseppe Castaldo, Chiara Dell’Isola, Roberta Russo, Armando Cevenini, Immacolata Andolfo, Mario Capasso, Giuseppe Fiorentino, Roberta Fedele, Gabriella Fabbrocini, Cecilia Calabrese, Marianna Caterino, Michele Costanzo, Ivan Gentile, Monica Gelzo, Roberto Parrella, Maurizio D’Abbraccio |
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| Přispěvatelé: | Caterino, Marianna, Costanzo, Michele, Fedele, Roberta, Cevenini, Armando, Gelzo, Monica, DI MINNO, Alessandro, Andolfo, Immacolata, Capasso, Mario, Russo, Roberta, Annunziata, Anna, Calabrese, Cecilia, Fiorentino, Giuseppe, D’Abbraccio, Maurizio, Dell’Isola, Chiara, Maria Fusco, Francesco, Parrella, Roberto, Fabbrocini, Gabriella, Gentile, Ivan, Castaldo, Giuseppe, Ruoppolo, Margherita, Caterino, M., Costanzo, M., Fedele, R., Cevenini, A., Gelzo, M., Di Minno, A., Andolfo, I., Capasso, M., Russo, R., Annunziata, A., Calabrese, C., Fiorentino, G., D'Abbraccio, M., Dell'Isola, C., Fusco, F. M., Parrella, R., Fabbrocini, G., Gentile, I., Castaldo, G., Ruoppolo, M. |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
coronavirus
Physiology Disease medicine.disease_cause Severity of Illness Index Medicine Biology (General) Amino Acids Spectroscopy Coronavirus mass spectrometry Discriminant Analysis General Medicine metabolomics Pathophysiology Computer Science Applications Amino Acid Chemistry Liver Metabolome Cytokines Discriminant Analysi Metabolic Networks and Pathways Human QH301-705.5 Nitrogen Coronaviru Context (language use) Metabolomic serum cytokines Catalysis Article Inorganic Chemistry Metabolomics Severity of illness Humans Physical and Theoretical Chemistry Least-Squares Analysis Serum cy-tokine Cytokine Molecular Biology QD1-999 Least-Squares Analysi business.industry SARS-CoV-2 Organic Chemistry lactic acid Metabolic Networks and Pathway COVID-19 Biomarker Metabolism Carbon business Biomarkers |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 9548, p 9548 (2021) International Journal of Molecular Sciences; Volume 22; Issue 17; Pages: 9548 |
| ISSN: | 1422-0067 |
| Popis: | COVID-19 is a global threat that has spread since the end of 2019, causing severe clinical sequelae and deaths, in the context of a world pandemic. The infection of the highly pathogenetic and infectious SARS-CoV-2 coronavirus has been proven to exert systemic effects impacting the metabolism. Yet, the metabolic pathways involved in the pathophysiology and progression of COVID-19 are still unclear. Here, we present the results of a mass spectrometry-based targeted metabolomic analysis on a cohort of 52 hospitalized COVID-19 patients, classified according to disease severity as mild, moderate, and severe. Our analysis defines a clear signature of COVID-19 that includes increased serum levels of lactic acid in all the forms of the disease. Pathway analysis revealed dysregulation of energy production and amino acid metabolism. Globally, the variations found in the serum metabolome of COVID-19 patients may reflect a more complex systemic perturbation induced by SARS-CoV-2, possibly affecting carbon and nitrogen liver metabolism. |
| Databáze: | OpenAIRE |
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