Efficacy of thyrotropin-releasing hormone in the treatment of spinal muscular atrophy

Autor: Yoshihiro Takeuchi, Akira Nishimura, Tadashi Sawada, Yuri Miyanomae, Hiroshi Komatsu, Tetuo Nishiki, Sozo Okano, Yoshikazu Oomizono
Rok vydání: 1994
Předmět:
Male
endocrine system
medicine.medical_specialty
medicine.medical_treatment
Thyrotropin-releasing hormone
Spinal Muscular Atrophies of Childhood
ELECTROMYOGRAPHIC FINDINGS
Motor function
Severity of Illness Index
03 medical and health sciences
0302 clinical medicine
030225 pediatrics
Internal medicine
medicine
Humans
Age of Onset
Child
Thyrotropin-Releasing Hormone
Spinal muscular atrophy type I
Motor Neurons
biology
business.industry
Electromyography
Infant
Newborn
Infant
Spinal muscular atrophy
medicine.disease
Median Nerve
Endocrinology
Treatment Outcome
Child
Preschool
Pediatrics
Perinatology and Child Health
biology.protein
Neurology (clinical)
Hormone therapy
Tibial Nerve
business
hormones
hormone substitutes
and hormone antagonists
030217 neurology & neurosurgery
Neurotrophin
Hormone
Zdroj: Journal of child neurology. 9(3)
ISSN: 0883-0738
Popis: Children with spinal muscular atrophy were treated by the administration of thyrotropin-releasing hormone. In three infants with spinal muscular atrophy type I, thyrotropin-releasing hormone showed little efficacy, but in children with types II and III, there was improvement in motor function and electromyographic findings after the thyrotropin-releasing hormone therapy. Thyrotropin-releasing hormone has a neurotrophic effect on the spinal anterior motor neurons of spinal muscular atrophy patients and thus may be warranted for the management of spinal muscular atrophy. (J Child Neurol 1994;9:287-289).
Databáze: OpenAIRE
Externí odkaz: