Increased levels of interleukin-32 isoforms alpha, beta, gamma, and delta in the gingival crevicular fluid and plasma of the patients with periodontitis
| Autor: | Cankat Kara, Figen Öngöz Dede, Bahattin Avci, Ceren Gökmenoğlu, Varol Çanakçi, Emre Taha Deveci, Selman Çelen |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Gene isoform medicine.medical_specialty Alpha (ethology) Gastroenterology Crevicular fluid 03 medical and health sciences Plasma 0302 clinical medicine Internal medicine medicine Humans Protein Isoforms In patient Beta (finance) Periodontitis business.industry Interleukins Interleukin 030206 dentistry Gingival Crevicular Fluid medicine.disease Interleukin 32 030104 developmental biology Periodontics business |
| Zdroj: | Journal of periodontal researchREFERENCES. 56(1) |
| ISSN: | 1600-0765 |
| Popis: | BACKGROUND AND OBJECTIVE Interleukin (IL)-32, which has been recently reported to be associated with periodontitis, has been suggested to have pleiotropic effect due to its 9 different isoforms. The aim of this study was to investigate the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in gingival crevicular fluid (GCF) and plasma before and after non-surgical periodontal treatment in patients with periodontitis (P). MATERIALS AND METHODS Twenty-seven P and 27 periodontally healthy controls (C) were recruited in this study. Non-surgical periodontal treatment was performed to periodontitis patients. GCF and plasma sampling and clinical periodontal parameters were evaluated before and 1 month after treatment. Enzyme-linked immunosorbent assay was used to analyze the levels of IL-32α, IL-32β, IL-32γ, IL-32δ isoforms in GCF and plasma samples. RESULTS The levels of IL-32α, IL-32β, IL-32γ, and IL-32δ in plasma and GCF were significantly higher in patients with periodontitis than healthy controls (P |
| Databáze: | OpenAIRE |
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