Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt sensitivity
| Autor: | Aaron Hoffman, Ehud Grossman, John R. Gill, Harry R. Keiser, David S. Goldstein |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male medicine.medical_specialty Urinary system Sodium Radioimmunoassay chemistry.chemical_element Blood Pressure Urine Peptide hormone Sodium Chloride Essential hypertension Pathogenesis Reference Values Internal medicine medicine Humans Chromatography High Pressure Liquid business.industry Endothelins Metabolism Diet Sodium-Restricted Middle Aged medicine.disease Endothelin 1 Endocrinology chemistry Nephrology Hypertension Female business |
| Zdroj: | Kidney International. 45(2):556-560 |
| ISSN: | 0085-2538 |
| DOI: | 10.1038/ki.1994.72 |
| Popis: | Urinary excretion rate of endothelin-1 in patients with essential hypertension and salt sensitivity. To assess the possible role of ET-1 in the pathogenesis of hypertension and salt sensitivity levels of immunoreactive endothelin-1 (irET-1) were measured in plasma and urine of 17 patients with essential hypertension and in 19 normotensive control subjects. Effects of alterations in dietary sodium content on urinary irET-1 levels also were assessed. Plasma levels of irET-1 did not differ between the hypertensives and normotensive groups (1.1 ± 0.3 and 1.3 ±0.1 pg/ml). Urine samples of both groups contained high concentrations of irET-1. However, the mean daily urinary excretion of irET-1 in the hypertensives was less than one-third that in controls (29 ± 3 vs. 109 ±21 ng/day, respectively, P < 0.01). Changing dietary sodium content in the hypertensives had no effect on mean irET-1 excretion. However, on either low, intermediate, or high salt diet, “salt sensitive” hypertensives had lower levels of the peptide than “salt resistant” patients (23 ± 3 vs. 36 ± 5 ng/day, respectively, P < 0.05). The data demonstrate a marked reduction in irET-1 excretion in patients with essential hypertension, despite normal plasma levels of the peptide. Since ET-1 has diuretic and natriuretic properties, the decreased renal excretion of ET-1 may be of relevance to the pathophysiology of hypertension and salt sensitivity. |
| Databáze: | OpenAIRE |
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