Immediate Effects of Chest Physiotherapy on Hemodynamic, Metabolic, and Oxidative Stress Parameters in Subjects With Septic Shock
| Autor: | Eamim D Squizani, Denizar Alberto da Silva Melo, Fernando Suparregui Dias, Clarissa Netto Blattner, Gabriela Silva, Leonardo Pedrazza, Jarbas Rodrigues de Oliveira, Rafael Saldanha dos Santos, Fernanda Bordignon Nunes, Isabella Gadegast, Márcio Vinícius Fagundes Donadio |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Partial Pressure Hemodynamics Blood Pressure Chest physiotherapy Suction Pulmonary compliance Nitric Oxide Critical Care and Intensive Care Medicine Thiobarbituric Acid Reactive Substances Vibration Respiratory Rate Heart Rate Transforming Growth Factor beta Intensive care Hypovolemia medicine Humans Lactic Acid Physical Therapy Modalities Aged Septic shock business.industry General Medicine Oxygenation Carbon Dioxide Hydrogen-Ion Concentration Middle Aged Thorax medicine.disease Shock Septic Surgery Oxygen Shock (circulatory) Anesthesia Female medicine.symptom business |
| Zdroj: | Respiratory Care. 59:1398-1403 |
| ISSN: | 1943-3654 0020-1324 |
| Popis: | Septic shock presents as a continuum of infectious events, generating tissue hypoxia and hypovolemia, and increased oxidative stress. Chest physiotherapy helps reduce secretion, improving dynamic and static compliance, as well as improving secretion clearance and preventing pulmonary complications. The purpose of this study was to evaluate the immediate effect of chest physiotherapy on hemodynamic, metabolic, inflammatory, and oxidative stress parameters in subjects in septic shock.We conducted a quasi-experimental study in 30 subjects in septic shock, who underwent chest physiotherapy, without associated heart diseases and with vasopressors0.5 μg/kg/min. Venous and arterial blood gases, clinical and hemodynamic data, inflammatory data, lactate, and oxidative stress were evaluated before and 15 min after physiotherapy.Thirty subjects with a mean age of 61.8 ± 15.9 y and Sequential Organ Failure Assessment of 8 (range 6-10) were included. Chest physiotherapy caused a normalization of pH (P = .046) and P(aCO2) (P = .008); reduction of lactate (P = .001); and an increase in P(aO2) (P = .03), arterial oxygen saturation (P = .02), and P(aO2)/F(IO2) (P = .034), 15 min after it was applied.The results indicate that chest physiotherapy has immediate effects, improving oxygenation and reducing lactate and oxidative damage in subjects in septic shock. However, it does not cause alterations in the inflammatory and hemodynamic parameters. |
| Databáze: | OpenAIRE |
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