Effects of cortistatin-14 and somatostatin-14 on the endocrine response to hexarelin in humans
| Autor: | C. Gauna, Flavia Prodam, A. J. van der Lely, Andrea Benso, S. Destefanis, Romano Deghenghi, Fabio Broglio, Ezio Ghigo, L. Filtri, C. Gottero |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Neuropeptide Peptides Cyclic Cortistatin (neuropeptide) Endocrinology Endocrine Glands Internal medicine medicine Humans Receptor Chemistry Insulin Neuropeptides Hormones Growth hormone secretion Kinetics Somatostatin Area Under Curve Secretagogue Corticotropic cell Oligopeptides human activities |
| Zdroj: | Università degli Studi del Piemonte Orientale-IRIS |
| ISSN: | 1720-8386 0391-4097 |
| DOI: | 10.1007/bf03347014 |
| Popis: | Cortistatin (CST)-14, a neuropeptide with high structural homology with somatostatine (SS)-14, binds all SS receptor subtypes but also shows activities not shared by SS. CST and SS are often co-expressed in the same neurons but are regulated by different stimuli. Moreover, CST, but not SS, also binds the GH secretagogue (GHS) receptor. We compared the effects of CST-14 and SS-14 (2.0 microg/kg/h i.v. from -30 to +90 min) on the endocrine response to hexarelin (HEX, 1.0 microg/kg i.v. at 0 min), a synthetic GHS, in 6 normal volunteers [age (mean+/-SEM): 28.7+/-2.9 yr; body mass index: 23.4+/-0.8 kg/m2]. GH, PRL, ACTH, cortisol, insulin and glucose levels were measured at each time point. CST-14 inhibited spontaneous GH secretion [delta-areas under curves (-AUC): -83.57+/-44.8 vs 2.3+/-2.7 microg/l/h, p0.01] to the same extent of SS-14 (-186.1+/-162.9 microg/l/h, p0.01). CST-14 as well as SS-14 also inhibited insulin secretion (p0.05). The GH response to HEX was similarly inhibited by either CST-14 (AUC: 3814.1+/-924.2 vs 1212.9+/-379.8 microg/l/h, p0.05) or SS-14 (720.9+/-158.6 microg/l/h, p0.05). HEX significantly increased PRL, ACTH and cortisol levels but these responses were not modified by either CST-14 or SS-14. The effects of CST-14 and SS-14 on insulin and glucose levels were not modified by HEX. In conclusion, this study shows that CST-14 inhibits the GH response to HEX to the same extent of SS-14. Like SS-14, CST-14 also inhibits insulin secretion but both do not modify the stimulatory effects of HEX on lactotroph and corticotroph secretion. Thus, CST-14 exerts full SS-14 activity in humans. |
| Databáze: | OpenAIRE |
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