Intrahippocampal Pathways Involved in Learning/Memory Mechanisms are Affected by Intracerebral Infusions of Amyloid-β25-35 Peptide and Hydrated Fullerene C60 in Rats
| Autor: | Ekaterina A. Mugantseva, Rita Ya. Gordon, Vasily Vorobyov, Sergey Khutsyan, Igor Podolski, Frank Sengpiel, Arkady N. Murashev, Alexander Deev, E. I. Makarova |
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| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Amyloid Hippocampus Hippocampal formation Q1 03 medical and health sciences Discrimination Psychological 0302 clinical medicine Limbic system Memory Neural Pathways medicine Animals Learning Rats Wistar Nootropic Agents Neurons Memory Disorders Amyloid beta-Peptides Chemistry musculoskeletal neural and ocular physiology General Neuroscience Dentate gyrus Amyloidosis Neurodegeneration General Medicine medicine.disease Entorhinal cortex Peptide Fragments Disease Models Animal Psychiatry and Mental health Clinical Psychology Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure nervous system Fullerenes Geriatrics and Gerontology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Alzheimer's Disease. 58:711-724 |
| ISSN: | 1875-8908 1387-2877 |
| DOI: | 10.3233/jad-161182 |
| Popis: | Primary memory impairments associated with increased level of amyloid-beta (Аβ) in the\ud brain have been shown to be linked, partially, with early pathological changes in the\ud entorhinal cortex (EC) which spread on the whole limbic system. While the hippocampus is\ud known to play a key role in learning and memory mechanisms, it is as yet unclear how its\ud structures are involved in the EC pathology. In this study, changes in memory and neuronal\ud morphology in male Wistar rats intrahippocampally injected with Аβ25–35 were correlated on\ud days 14 and 45 after the injection to reveal specific cognitive - structural associations. The\ud main focus was on the dentate gyrus (DG) and hippocampal areas of CA1 and CA3 because\ud of their involvement in afferent flows from EC to the hippocampus through tri-synaptic (EC \ud DG CA3 CA1) and/or mono-synaptic (EC CA1) pathways. Evident memory\ud impairments were observed at both time points after Аβ25–35 injection. However, on day 14,\ud populations of morphological intact neurons were decreased in CA3 and, drastically, in CA1,\ud and the DG supramedial bundle was significantly damaged. On day 45, this bundle largely\ud and СА1 neurons partially recovered, whereas CA3 neurons remained damaged. We\ud suggest that Аβ25–35 primarily affects the tri-synaptic pathway, destroying the granular cells in\ud the DG supramedial area and neurons in CA3 and, through the Schaffer collaterals, in CA1.\ud Intrahippocampal pretreatment with hydrated fullerene С60 allows the neurons and their\ud connections to survive the amyloidosis, thus supporting the memory mechanisms. |
| Databáze: | OpenAIRE |
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