Preliminary evidence for a role of apolipoprotein E alleles in identifying haemodialysis patients at high vascular risk
| Autor: | M Olmer, J E Renucci, Raj Purgus, R Planells, D. Bouchouareb |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Apolipoprotein E medicine.medical_specialty Pathology Arteriosclerosis Carotid Artery Common medicine.medical_treatment Apolipoprotein E4 Vascular risk Cohort Studies Apolipoproteins E Renal Dialysis Risk Factors Internal medicine medicine Humans Vascular Diseases Risk factor Allele Alleles Aged Ultrasonography Transplantation Vascular disease business.industry Middle Aged medicine.disease Lipids Nephrology Cohort Female Hemodialysis business Complication |
| Zdroj: | Nephrology Dialysis Transplantation. 12:691-693 |
| ISSN: | 1460-2385 0931-0509 |
| DOI: | 10.1093/ndt/12.4.691 |
| Popis: | Conventional risk factors have very low predictive power in identifying haemodialysis patients at high risk of vascular accidents. A role for apolipoprotein E isotypes was looked for in a small, but rigorously defined, cohort of longterm haemodialysis patients. In individuals with high vascular risk, as identified by higher common carotid intima/media thickness, we found an excess of apolipoprotein E4 alleles. This preliminary result requires confirmation in large patient cohorts. |
| Databáze: | OpenAIRE |
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