The prevalence of A2 and A2B subgroups in blood donors at a tertiary care teaching hospital blood bank of Rayalaseema region: a pilot study

Autor: Anju Verma, Chaitanya Kumar Is, Suresh Babu B, Jothi Bai Ds, Sreedhar Babu Kv, Yashovardhan A
Rok vydání: 2012
Předmět:
Zdroj: Journal of Clinical and Scientific Research, Vol 01, Iss 01, Pp 50-50 (2012)
ISSN: 2277-8357
2277-5706
DOI: 10.15380/2277-5706.jcsr.12.012
Popis: Polymorphisms in the genes coding for A gene leads to subgroups of A. No published data regarding the prevalence of subgroups of A blood group in Andhra Pradesh, India is available. The importance of subgrouping is that the A antigens in various subgroups may differ both quantitatively and qualitatively 1 . Some individuals with blood groups A2, A3, Ax, Ael, Aend, A2B etc., have anti-A1 antibodies and may present problems in blood grouping. At our center, the typing of A subgroup of all blood donors was done using commercial anti A1 lectin, anti-A and anti-AB antisera as per the manufacturer’s instructions. On analysis of a total of 5,505 blood groupings over a period of one year, 1,486(27%) individuals had A antigen. Of these, 1,137 (20.7%) were typed as A group and 349 (6.3%) as AB group based on the presence of associated B antigen. Of the 1,137 A group individuals,1,090(95.9%) had A1 antigen (subgroup A1) and the rest 47(4.1%) had no detectable A1 antigen (subgroup A2). Similarly among the 349 AB group individuals, 282(80.8%) had A1 antigen (subgroup A1B) and 67(19.2%) had no detectable A1 antigen (subgroup A2B). The number of individuals who lack A1 antigen is less among A group individuals in contrast to AB group individuals and this difference was found to be statistically significant (p
Databáze: OpenAIRE