Cardiac findings in Quarter Horses with heritable equine regional dermal asthenia
| Autor: | Bryn Brazile, Ryan M. Centini, Jun Liao, Erin Brinkman, Benjamin C. Weed, Jim Cooley, Ann M. Rashmir-Raven, Bari Olivier, Sourav S. Patnaik, Robert W. Wills, Dodd G. Sledge |
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| Rok vydání: | 2017 |
| Předmět: |
Male
Aortic valve medicine.medical_specialty Heart Diseases 040301 veterinary sciences 030204 cardiovascular system & hematology Body weight Skin Diseases 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Mitral valve Internal medicine medicine.artery medicine Animals Genetic Predisposition to Disease Clinical significance Horses Heart valve Aorta General Veterinary business.industry Case-control study 04 agricultural and veterinary sciences Surgery medicine.anatomical_structure Echocardiography Asthenia Case-Control Studies Collagen disorder Cardiology Female Horse Diseases business |
| Zdroj: | Journal of the American Veterinary Medical Association. 250:538-547 |
| ISSN: | 0003-1488 |
| DOI: | 10.2460/javma.250.5.538 |
| Popis: | OBJECTIVE To compare biomechanical and histologic features of heart valves and echocardiographic findings between Quarter Horses with and without heritable equine regional dermal asthenia (HERDA). DESIGN Prospective case-control study. ANIMALS 41 Quarter Horses. PROCEDURES Ultimate tensile strength (UTS) of aortic and mitral valve leaflets was assessed by biomechanical testing in 5 horses with HERDA and 5 horses without HERDA (controls). Histologic evaluation of aortic and mitral valves was performed for 6 HERDA-affected and 3 control horses. Echocardiography was performed in 14 HERDA-affected and 11 control horses. Biomechanical data and echocardiographic variables of interest were compared between groups by statistical analyses, RESULTS Mean values for mean and maximum UTS of heart valves were significantly lower in HERDA-affected horses than in controls. Blood vessels were identified in aortic valve leaflets of HERDA-affected but not control horses. Most echocardiographic data did not differ between groups. When the statistical model for echocardiographic measures was controlled for body weight, mean and maximum height and width of the aorta at the valve annulus in short-axis images were significantly associated with HERDA status and were smaller for affected horses. CONCLUSIONS AND CLINICAL RELEVANCE Lower UTS of heart valves in HERDA-affected horses, compared with those of control horses, supported that tissues other than skin with high fibrillar collagen content are abnormal in horses with HERDA. Lack of significant differences in most echocardiographic variables between affected and control horses suggested that echocardiography may not be useful to detect a substantial loss of heart valve tensile strength. Further investigation is warranted to confirm these findings. Studies in horses with HERDA may provide insight into cardiac abnormalities in people with collagen disorders. |
| Databáze: | OpenAIRE |
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