Effect of cerebral ischemia and hypercapnia on cerebral pH studied with 31P-NMR and electrical activity in rat brain
| Autor: | Kazuo Yoshizaki, Takao Motonaga, Shod Naruse, Hiroyasu Nishikawa, Kimiyoshi Hirakawa, Yoshiaki Takanashi |
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| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
Magnetic Resonance Spectroscopy Physiology Central nervous system Ischemia Electroencephalography Phosphocreatine Brain Ischemia Hypercapnia chemistry.chemical_compound Internal medicine Evoked Potentials Somatosensory medicine Animals Evoked potential medicine.diagnostic_test Chemistry Brain Phosphorus Rats Inbred Strains General Medicine Hydrogen-Ion Concentration medicine.disease Rats Electrophysiology medicine.anatomical_structure Endocrinology Somatosensory evoked potential Anesthesia medicine.symptom |
| Zdroj: | The Japanese journal of physiology. 39(1) |
| ISSN: | 0021-521X |
| Popis: | The activity of electroencephalogram (EEG) and cortical somatosensory evoked potential (SEP) was suppressed during cerebral Ischemia in rats subjected to the 4-vessel occlusion. Considerable variations were demonstrated in the decrease of phosphocreatine and ATP concentration during ischemia among the rats measured with 31P-NMR, accompanied with cerebral acidification. Hypercapnia, induced in the rats studied by the inhalation of a gas mixture of 3O-4O% CO2, suppressed the activity of EEG and cortical SEP. The cerebral acidification observed during the ischemia was more severe than that under the hypercapnia, implying that cerebral acidification is one of the possible causes for the decrease in the electrical activity of the brain during ischemia. |
| Databáze: | OpenAIRE |
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