Reusable nanostencils for creating multiple biofunctional molecular nanopatterns on polymer substrate
| Autor: | Min Huang, Hatice Altug, Betty C. Galarreta, Alp Artar, Serap Aksu, Ronen Adato |
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| Rok vydání: | 2012 |
| Předmět: |
reusable
Materials science nanostencil lithography Macromolecular Substances Polymers Surface Properties Molecular Conformation Bioengineering Nanotechnology Substrate (printing) biofunctional Stencil Molecular Imprinting Biopolymers Materials Testing Polymer substrate General Materials Science Particle Size Nanoscopic scale Lithography Reusability chemistry.chemical_classification Flexibility (engineering) Mechanical Engineering Biomolecule protein nanoarray General Chemistry Condensed Matter Physics Nanostructures chemistry Bio atterning Crystallization |
| Zdroj: | Nano letters. 12(9) |
| ISSN: | 1530-6992 |
| Popis: | In this paper, we demonstrate a novel method for high throughput patterning of bioprobes with nanoscale features on biocompatible polymer substrate. Our technique, based on nanostencil lithography, employs high resolution and robust masks integrated with array of reservoirs. We show that the smallest pattern size can reach down to 100 nm. We also show that different types of biomolecules can be patterned on the same substrate simultaneously. Furthermore, the stencil can be reused multiple times to generate a series of identical patterns at low cost. Finally, we demonstrate that biomolecules can be covalently patterned on the surface while retaining their biofunctionalities. By offering the flexibility on the nanopattern design and enabling the reusability of the stencil, our approach significantly simplifies the bionanopatterning process and therefore could have profound implications in diverse biological and medical applications. |
| Databáze: | OpenAIRE |
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