Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy
| Autor: | Mark T. Wagner, Berra Yazar-Klosinski, Lisa Jerome, Rick Doblin, Ann T Mithoefer, Rebecca K. MacAulay, Michael C. Mithoefer |
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| Rok vydání: | 2017 |
| Předmět: |
Hallucinogen
Adult Male Psychotherapist MDMA openness Personality Inventory media_common.quotation_subject N-Methyl-3 4-methylenedioxyamphetamine Stress Disorders Post-Traumatic 03 medical and health sciences Young Adult pharmacotherapy 0302 clinical medicine mental disorders medicine Openness to experience Personality Humans Pharmacology (medical) Big Five personality traits media_common Pharmacology Neuroticism Mechanism (biology) posttraumatic stress disorder (PTSD) Combined Modality Therapy Original Papers NEO personality 030227 psychiatry psychotherapy Psychiatry and Mental health Treatment Outcome Hallucinogens Female sense organs Personality Assessment Inventory Psychology 030217 neurology & neurosurgery Clinical psychology medicine.drug |
| Zdroj: | Journal of Psychopharmacology (Oxford, England) |
| ISSN: | 1461-7285 |
| Popis: | A growing body of research suggests that traumatic events lead to persisting personality change characterized by increased neuroticism. Relevantly, enduring improvements in Post-Traumatic Stress Disorder (PTSD) symptoms have been found in response to 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy. There is evidence that lasting changes in the personality feature of “openness” occur in response to hallucinogens, and that this may potentially act as a therapeutic mechanism of change. The present study investigated whether heightened Openness and decreased Neuroticism served as a mechanism of change within a randomized trial of MDMA-assisted psychotherapy for chronic, treatment-resistant PTSD. The Clinician-Administered PTSD Scale (CAPS) Global Scores and NEO PI-R Personality Inventory (NEO) Openness and Neuroticism Scales served as outcome measures. Results indicated that changes in Openness but not Neuroticism played a moderating role in the relationship between reduced PTSD symptoms and MDMA treatment. Following MDMA-assisted psychotherapy, increased Openness and decreased Neuroticism when comparing baseline personality traits with long-term follow-up traits also were found. These preliminary findings suggest that the effect of MDMA-assisted psychotherapy extends beyond specific PTSD symptomatology and fundamentally alters personality structure, resulting in long-term persisting personality change. Results are discussed in terms of possible mechanisms of psychotherapeutic change. |
| Databáze: | OpenAIRE |
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