A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health
| Autor: | Nathan S. Bryan, Matthew I Geluz, Melissa J Banez, Ernst R. Schwarz, Tesnim Hamdan, Olivia S. Biswas, Anjali Chandra |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Antioxidant Cardiotonic Agents Curcumin medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment 030209 endocrinology & metabolism Inflammation Resveratrol Pharmacology medicine.disease_cause Nitric Oxide Cardiovascular System Anti-inflammatory Antioxidants Nitric oxide Cardiovascular Physiological Phenomena 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology Medicine Animals Humans Cardioprotection Clinical Trials as Topic 030109 nutrition & dietetics Nutrition and Dietetics business.industry Anti-Inflammatory Agents Non-Steroidal chemistry Cardiovascular Diseases Dietary Supplements medicine.symptom business Oxidative stress |
| Zdroj: | Nutrition research (New York, N.Y.). 78 |
| ISSN: | 1879-0739 |
| Popis: | The potential benefits of supplemental nutrients and dietary interventions against cardiovascular morbidity and mortality have been extensively investigated throughout the years. Numerous supplements claim cardioprotection and reduction of cardiovascular risk factors, but the roles of many supplements have not been determined. In the vast number of supplements on the market asserting cardioprotective effects, only 3 have been thoroughly evaluated and consistently reported as effective by our clinic patients. They have used supplements such as fish oil, multivitamins, and calcium, but many had not known of the benefits of resveratrol, curcumin, and nitric oxide as supplements for improving cardiovascular health. The cardioprotective effects of these dietary supplements in both animal models and humans have been explored with proposed mechanisms of action mostly attributed to antioxidant and anti-inflammatory properties. Resveratrol is one of the most studied polyphenols with established cardiovascular benefits. Preclinical studies have demonstrated these effects exerted via improved inflammatory markers, atherogenic profile, glucose metabolism, and endothelial function and are further supported by clinical trials. Curcumin has a well-established anti-inflammatory role by regulating numerous transcription factors and cytokines linked to inflammation. Inflammation is an underlying pathology in cardiovascular diseases, rendering curcumin a potential therapeutic compound. Similarly, nitric oxide supplementation has demonstrated cardiovascular benefits by normalizing blood pressure; enhancing blood flow; and reducing inflammation, immune dysfunction, and oxidative stress. A comprehensive review was performed evaluating the cardioprotective effects of these 3 dietary supplements with hope to provide updated information, promote further awareness of these supplements, and inspire future studies on their effects on cardiovascular health. |
| Databáze: | OpenAIRE |
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