Mesenchymal Stem Cells and C-type Natriuretic Peptide Signaling: A Proposal for a New Treatment Approach for Skeletal Dysplasias
| Autor: | Ahmet Cevik Tufan, Murat Serkant Unal |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) Fibroblast growth factor Extracellular matrix Osteochondrodisyplasia 0302 clinical medicine Natriuretic peptide mesenchymal stem cell 030222 orthopedics bone dysplasia General Medicine natriuretic peptide receptor B musculoskeletal development Hedgehog signaling pathway Cell biology priority journal tissue engineering trabecular bone natriuretic peptide type C Skeletal dysplasia natriuretic factor mesenchymal stem cell transplantation growth rate signal transduction medicine.medical_specialty in vitro study phenotype medicine.drug_class Dwarfism Biology brain natriuretic peptide Article Achondroplasia 03 medical and health sciences Internal medicine medicine human protein expression Endochondral ossification nonhuman Mesenchymal stem cell Natriuretic peptide receptor-B 030104 developmental biology Endocrinology GDF11 Mesenchymal stem cells enchondral ossification atrial natriuretic factor C-type natriuretic peptide Transforming growth factor |
| Zdroj: | Current Stem Cell Research & Therapy. 11:513-521 |
| ISSN: | 1574-888X |
| DOI: | 10.2174/1574888x10666150202145939 |
| Popis: | Endochondral ossification is under the regulation of endocrine, paracrine and otocrine factors including transforming growth factor-β superfamily members, fibroblast growth factors, retinoids, products of hedgehog gene, parathyroid hormone-related peptide, molecules involved in cell adhesion, and extracellular matrix components. Natriuretic peptide receptor-B, and its ligand C-type natriuretic peptide have also been implicated in the regulation of limb bone development. Results of recent studies are promising in terms of systemic elevation of C-type natriuretic peptide level inducing growth. In addition, same strategy also overcomes the dwarf phenotype of achondroplasia, the most frequently seen skeletal dysplasia in human, in a mouse model. Based on this literature and a series of recent experiments discussed here, this perspective underlines the abundant C-type natriuretic peptide expression in trabecular bone derived mesenchymal stem cells of human, chicken, and rat origin, and proposes the potential use of mesenchymal stem cells as a part of growth inducing treatment strategy in osteochondrodisyplasias in the future. © 2016 Bentham Science Publishers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|