STAT4 is required for IL-23 responsiveness in Th17 memory cells and NKT cells
| Autor: | Nicole L. Glosson-Byers, Mark H. Kaplan, Sarita Sehra |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
business.industry medicine.medical_treatment T cell hemic and immune systems General Medicine Acquired immune system Natural killer T cell Cytokine medicine.anatomical_structure Immunity immune system diseases Immunology medicine Secretion IL-2 receptor business skin and connective tissue diseases STAT4 Original Research |
| Zdroj: | JAK-STAT. 3(3) |
| ISSN: | 2162-3988 |
| Popis: | STAT4 is a critical mediator of inflammatory immunity and is required for all known IL-12 biological responses, including the induction of IFN-γ and development of Th1 cells. We demonstrate that IL-23, an IL-12-related cytokine, also requires STAT4 for optimal IL-17 secretion from memory T helper cells and NKT cells. Although IL-23 stimulation had modest effects on STAT4 activation, STAT4-deficiency results in reduced Il23r expression. These data demonstrate a restricted requirement for STAT4 in innate and adaptive IL-17-secreting T cell responses that might contribute to inflammatory immunity. |
| Databáze: | OpenAIRE |
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