β-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans
| Autor: | Sandeep B. Rajput, S. Mohan Karuppayil |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Antifungal Agents
Morphogenesis Pharmaceutical Science Allylbenzene Derivatives Microbial Sensitivity Tests Anisoles Microbiology Ergosterol Candida albicans Drug Discovery Acorus calamus Pharmacology Dose-Response Relationship Drug biology Acorus Biofilm biology.organism_classification Corpus albicans Rhizome Fungicide Complementary and alternative medicine Biofilms Molecular Medicine Ergosterol biosynthesis |
| Zdroj: | Phytomedicine. 20:139-142 |
| ISSN: | 0944-7113 |
| DOI: | 10.1016/j.phymed.2012.09.029 |
| Popis: | Anti-Candida potential of Acorus calamus rhizome and its active principle, β-asarone, was evaluated against the human fungal pathogen, Candida albicans. β-Asarone exhibited promising growth inhibitory activity at 0.5 mg/ml and it was fungicidal at 8 mg/ml. Time dependant kill curve assay showed that MFC of β-asarone was highly toxic to C. albicans, killing 99.9% inoculum within 120 min of exposure. β-Asarone caused significant inhibition of C. albicans morphogenesis and biofilm development at sub-inhibitory concentrations. Our data indicate that the growth inhibitory activity of β-asarone might be through inhibition of ergosterol biosynthesis. Hemolytic assay showed that β-asarone is non-toxic, even at concentrations approaching MIC value. Our results suggest that β-asarone may be safe as a topical antifungal agent. |
| Databáze: | OpenAIRE |
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