Multideterminant role of calcium in hippocampal synaptic plasticity

Autor:	Timothy J. Teyler, C. Coussens, I. Cavus, Z. Little, Lawrence M. Grover, Y. P. Lee, Pascal Discenna
Rok vydání:	1994
Předmět:	Neuronal Plasticity Synaptic scaling Homosynaptic plasticity Chemistry Cognitive Neuroscience fungi Nonsynaptic plasticity Long-term potentiation Hippocampus Synaptic fatigue Synaptic augmentation Synapses Synaptic plasticity Metaplasticity Animals Humans Calcium Neuroscience
Zdroj:	Hippocampus. 4:623-634
ISSN:	1098-1063 1050-9631
DOI:	10.1002/hipo.450040602
Popis:	Hippocampal CA1 cells possess several varieties of long-lasting synaptic plasticity: two different forms of long-term potentiation (LTP) and at least one form of long-term depression (LTD). All forms of synaptic plasticity are induced by afferent activation, all involve Ca2+ influx, all can be blocked by Ca2+ chelators, and all activate Ca2+-dependent mechanisms. The question arises as how different physiological responses can be initiated by activation of the same second messenger. We consider two hypotheses which could account for these phenomena: voltage-dependent differences in cytosolic Ca2+ concentration acting upon Ca2+ substrates of differing Ca2+ affinities and compartmentalization of the Ca2+ and its substrates. © 1994 Wiley-Liss, Inc.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16a11bfa5e234e98217e67e5c22f4ebc https://doi.org/10.1002/hipo.450040602 Zobrazit plný text záznamu Plný text