Two Elderly Patients with Philadelphia Chromosome Positive Mixed Phenotype Acute Leukemia Who Were Successfully Treated with Dasatinib and Prednisolone
| Autor: | Hitohiro Sasaki, Masao Ogata, Hiroyuki Takata, Yasuhiko Miyazaki, Kuniaki Shirao, Yoshio Saburi, Eiichi Ohtsuka, Taichi Ikebe |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Myeloid Combination therapy Prednisolone Dasatinib Philadelphia chromosome Gastroenterology 03 medical and health sciences 0302 clinical medicine Pharmacotherapy hemic and lymphatic diseases Internal medicine Internal Medicine medicine Humans Philadelphia Chromosome Aged Acute leukemia Philadelphia Chromosome Positive business.industry General Medicine Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease medicine.anatomical_structure Phenotype Treatment Outcome 030220 oncology & carcinogenesis Acute Disease Drug Therapy Combination Female business 030215 immunology medicine.drug |
| Zdroj: | Internal medicine (Tokyo, Japan). 55(9) |
| ISSN: | 1349-7235 |
| Popis: | Philadelphia chromosome positive (Ph+) mixed phenotype acute leukemia (MPAL) is a rare type of acute leukemia having both myeloid and lymphoid features for which no optimal treatment has yet been established. We herein describe two elderly Ph+MPAL patients who achieved molecular remission without any serious adverse events by treatment with dasatinib and prednisolone. Although dasatinib induction therapy combined with prednisolone is known to be a highly effective treatment for Ph+ acute lymphoblastic leukemia, its efficacy for Ph+MPAL has not been shown. The clinical courses of the present cases suggest that combination therapy with dasatinib and prednisolone is a safe and effective therapeutic modality in elderly Ph+MPAL patients. |
| Databáze: | OpenAIRE |
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