Assessing mobility in primary brain tumor patients: A descriptive feasibility study using two established mobility tests

Autor: James L Rogers, Julianie De La Cruz Minyety, Elizabeth Vera, Alvina A Acquaye, Samuel S Payén, Jeffrey S Weinberg, Terri S Armstrong, Shiao-Pei S Weathers
Rok vydání: 2022
Předmět:
Zdroj: Neurooncol Pract
ISSN: 2054-2585
2054-2577
DOI: 10.1093/nop/npac013
Popis: Background Patients with primary brain tumors (PBT) face significant mobility issues related to their disease and/or treatment. Here, the authors describe the preliminary utility and feasibility of two established mobility measures, the Timed-Up-and-Go (TUG) and Five-Times Sit-to-Stand (TSS) tests, in quickly and objectively assessing the mobility status of PBT patients at a single institution’s neuro-oncology clinic. Methods Adult patients undergoing routine PBT care completed the TUG/TSS tests and MD Anderson Symptom Inventory-Brain Tumor module (MDASI-BT), which assessed symptom burden and interference with daily life, during clinic visits over a 6-month period. Research staff assessed feasibility metrics, including test completion times/rates, and collected demographic, clinical, and treatment data. Mann–Whitney tests, Kruskal–Wallis tests, and Spearman’s rho correlations were used to interrogate relationships between TUG/TSS test completion times and patient characteristics. Results The study cohort included 66 PBT patients, 59% male, with a median age of 47 years (range: 20–77). TUG/TSS tests were completed by 62 (94%) patients. Older patients (P < .001) and those who were newly diagnosed (P = .024), on corticosteroids (P = .025), or had poor (≤80) KPS (P < .01) took longer to complete the TUG/TSS tests. Worse activity-related (work, activity, and walking) interference was associated with longer TUG/TSS test completion times (P < .001). Conclusions The TUG/TSS tests are feasible for use among PBT patients and may aid in clinical care. Older age, being newly diagnosed, using corticosteroids, poor (≤80) KPS, and high activity-related interference were associated with significant mobility impairment, highlighting the tests’ potential clinical utility. Future investigations are warranted to longitudinally explore feasibility and utility in other practice and disease settings.
Databáze: OpenAIRE
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