Ameliorative effect of apelin-13 against renal complications in L-NAME-induced preeclampsia in rats
| Autor: | Abdel Aziz A. Diab, Ali Khalil Asalah, Suzan M. M. Moursi, Reham Z. Hamza, Mansour H. Zahra, Mai S. Attia |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Histology Adipokine lcsh:Medicine 030204 cardiovascular system & hematology Biochemistry General Biochemistry Genetics and Molecular Biology Preeclampsia 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Endothelial dysfunction 030304 developmental biology 0303 health sciences Creatinine Kidney Proteinuria business.industry General Neuroscience lcsh:R General Medicine medicine.disease Apelin Endocrinology Blood pressure medicine.anatomical_structure chemistry Kidney injury medicine.symptom General Agricultural and Biological Sciences business |
| Zdroj: | PeerJ, Vol 9, p e11110 (2021) PeerJ |
| ISSN: | 2167-8359 |
| Popis: | Pre-eclampsia (PE) accompanying acute liver and kidney injury has remained a master cause of both fetal and maternal mortality and morbidity. Vasoactive mediators, oxidative stress and inflammatory imbalanceshave an important role in PE pathogenesis. Apelin is an adipokine that improves endothelial dysfunction; has anti-inflammatory and antioxidant effects; moreover, its level reduced during PE. This study aimed to explore the effects of apelin-13 administration on preeclampsia-associated renal dysfunction and proteinuria. Thirty-three pregnant female rats were divided into three groups; group: 1 (normal pregnant rats), group: 2 (preeclamptic rats); where rats were injected subcutaneously with 75 mg L-NAME/ kg body weight/day beginning from 9th to 20th day of pregnancy andgroup 3 (apelin-13 treated preeclamptic rats); In which L-NAME-induced preeclamptic rats were subcutaneously injected with 6 × 10−8 mol apelin-13/kg body weight/twice daily starting from 6th to 20th day of pregnancy. In all groups, mean arterial blood pressure, total urine protein, serum urea, creatinine, nitric oxide (NO), endothelin-1 (ET-1), interleukin–6 (IL-6) and malondialdhyde (MDA) were measured. Histopathological examination of kidney tissues was also done. preeclamptic rats showed significantly increased mean arterial blood pressure, total urine proteins, serum urea, creatinine, ET-1, IL-6, and MDA, but revealed a significantly decreased serum NO level. On the other hand, apelin treatment significantly improved these parameters together with amelioration of kidney histoarchitecture in the treated group. In conclusion, apelin may be a potentially curative candidate for prohibiting kidney damage and have a therapeutic benefit in PE rat models. |
| Databáze: | OpenAIRE |
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