SDN-POA volume, sexual behavior and partner preference of male rats affected by perinatal treatment with ATD
| Autor: | N.E. van de Poll, A.K. Slob, F.H. de Jonge, R.N.J.M.A. Joosten, E. J. Houtsmuller, T. Brand |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1994 |
| Předmět: |
Male
Sexual behavior endocrine system medicine.medical_specialty Sex Differentiation media_common.quotation_subject Experimental and Cognitive Psychology Biology Perinatal Behavioral Neuroscience Sexual Behavior Animal Pregnancy Internal medicine Male rats medicine Veehouderij Animals Sexual Maturation Animal Husbandry Rats Wistar Sexually dimorphic nucleus media_common Sex Characteristics Sexual differentiation Androstatrienes SDN-POA Organ Size medicine.disease ATD Preoptic Area Rats Preoptic area Sexual dimorphism Endocrinology Hypothalamus Prenatal Exposure Delayed Effects WIAS Aromatization Female Reproduction Masculinization Sex characteristics |
| Zdroj: | Physiology and Behavior 56 (1994) Physiology and Behavior, 56, 535-541 |
| ISSN: | 0031-9384 |
| Popis: | The present study investigated 1) the importance of the aromatization process during the perinatal period for the development of the sexually dimorphic nucleus in the preoptic area of the hypothalamus (SDN-POA) of male rats, and 2) the relationship between SDN-POA volume and parameters of masculinization in male rats that were treated perinatally with the aromatase-inhibitor ATD. Males were treated with ATD either prenatally or pre- and neonatally, or with the vehicle. Masculine sexual behavior and partner preference were investigated in adulthood. Thereafter, animals were sacrificed and SDN-POA volume was measured. The SDN-POA volume was reduced in both the prenatally and the pre- and neonatally treated group, with a larger reduction in the latter than in the former group. Combined pre- and neonatal ATD treatment resulted in reduced frequency of mounts, intromissions, and ejaculations, as well as a reduced preference for a female over a male. The SDN-POA size was significantly and positively correlated with frequency of masculine sexual behavior, as well as preference for a female over a male. |
| Databáze: | OpenAIRE |
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