Drug therapy reviews: Nitrofurantoin
| Autor: | Rtcliard Gleckman, Salvador Alvarez, Dennis W. Joubert |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Lung Diseases
Adult Male medicine.medical_specialty Urinary system Microbial Sensitivity Tests urologic and male genital diseases Intestinal absorption Pharmacotherapy Recurrence Internal medicine medicine Humans Drug Interactions Tissue Distribution Child Intensive care medicine Adverse effect Pharmacology business.industry Health Policy Bacterial Infections bacterial infections and mycoses medicine.disease Antimicrobial Hematologic Diseases female genital diseases and pregnancy complications Chronic bacterial prostatitis Intestinal Absorption Nitrofurantoin Child Preschool Bacteremia Urinary Tract Infections Kidney Diseases Female Chemical and Drug Induced Liver Injury Nervous System Diseases business medicine.drug |
| Zdroj: | American Journal of Health-System Pharmacy. 36:342-351 |
| ISSN: | 1535-2900 1079-2082 |
| DOI: | 10.1093/ajhp/36.3.342 |
| Popis: | Mechanism of action, antimicrobial spectrum, pharmacology, adverse reactions and therapeutic uses of nitrofurantoin, a broad-spectrum antimicrobial agent, are discussed. The frequency and potential severity of reactions attributed to nitrofurantoin, plus its inability to achieve therapeutic blood concentrations, relegate this drug to a position of secondary importance. Nitrofurantoin compares favorably with other standard agents for the therapy of acute and recurrent urinary tract infections in women which may be caused by susceptible organisms, and it is an effective chemoprophylactic agent for patients with recurrent urinary tract infections. The compound has no apparent adverse effects on the developing fetus and can be used in pregnant women. This is not sanctioned by the package insert, however. Nitrofurantoin should not be administered when the possibility of bacteremia exists, as the drug does not achieve therapeutic serum levels when administered orally. Nitrofurantoin is contraindicated for patients with renal insufficiency. The value of this compound for men with acute urinary tract infection, recurrent urinary tract infection, acute bacterial prostatitis or chronic bacterial prostatitis has not been established. There are no indications for prescribing parenteral nitrofurantoin. |
| Databáze: | OpenAIRE |
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