Percutaneous Treatment With Drug-Eluting Stent vs Bypass Surgery in Patients Suffering From Chronic Stable Angina With Multivessel Disease Involving Significant Proximal Stenosis in Left Anterior Descending Artery

Autor: Zhou Yujie, Kang Junping, Jia Changqi, Dong Jianzeng, Ma Changsheng, Lv Shuzheng, Zhang Yin, Wu Jiahui, Qiao Yan, Chen Fang, Du Xin, Lv Qiang, Hu Rong, Huang Fangjiong, Gu Chengxiong, Liu Xiaohui, Nie Shaoping, Liu Xinmin, Wu Xuesi
Rok vydání: 2009
Předmět:
Male
Time Factors
medicine.medical_treatment
Myocardial Infarction
Kaplan-Meier Estimate
Coronary Angiography
Severity of Illness Index
Coronary artery disease
Odds Ratio
Hospital Mortality
Registries
Myocardial infarction
Angioplasty
Balloon
Coronary
Coronary Artery Bypass
Drug-Eluting Stents
General Medicine
Middle Aged
Treatment Outcome
medicine.anatomical_structure
Bypass surgery
Drug-eluting stent
Cardiology
Female
Cardiology and Cardiovascular Medicine
Artery
Reoperation
medicine.medical_specialty
Paclitaxel
Revascularization
Risk Assessment
Angina Pectoris
Internal medicine
medicine
Humans
cardiovascular diseases
Aged
Proportional Hazards Models
Retrospective Studies
Sirolimus
business.industry
Coronary Stenosis
Percutaneous coronary intervention
Cardiovascular Agents
medicine.disease
Surgery
Cerebrovascular Disorders
Stenosis
Chronic Disease
business
Platelet Aggregation Inhibitors
Zdroj: Circulation Journal. 73:1848-1855
ISSN: 1347-4820
1346-9843
Popis: Background: The aim of the present study was to compare the effects of drug-eluting stents (DES) and coronary artery bypass grafting (CABG) in patients suffering from chronic stable angina with multivessel disease, involving significant proximal stenosis in the left anterior descending artery (LAD). Methods and Results: All consecutive patients suffering from chronic stable angina with multivessel disease involving significant proximal LAD stenosis underwent DES implantation (n=600) or CABG (n=709) at our institution. At 2 years, the unadjusted mortality was significantly lower in the DES group than in the CABG group (2.2% vs 5.2%, P=0.004), but the adjusted risk of death was similar (odds ratio (OR) 0.74, 95%CI 0.28-1.97, P=0.555). Furthermore, both the adjusted rate of nonfatal myocardial infarction and cerebrovascular events was also comparable. However, the unadjusted and adjusted risk of major adverse cardiac cerebrovascular events in the DES was significantly higher than in the CABG (13.3% vs 9.6%, OR 2.71, 95%CI 1.56-4.74, P
Databáze: OpenAIRE
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