Dexamethasone Prevents the Decrease of Bone Mineral Density in Type II Collagen-Induced Rat Arthritis Model
| Autor: | Tatsuo Suzuki, Toshiki Takagi, Ryuichi Totsuka, Isao Takata, Peter W. Tsao, Takashi Murata |
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| Rok vydání: | 1998 |
| Předmět: |
musculoskeletal diseases
medicine.medical_specialty Time Factors Anti-Inflammatory Agents Type II collagen Arthritis Hindlimb Dexamethasone Dinoprostone Bone Density Oral administration Internal medicine medicine Animals Edema Femur Pharmacology Bone mineral Foot Histocytochemistry Chemistry musculoskeletal neural and ocular physiology musculoskeletal system medicine.disease Rats Disease Models Animal Endocrinology Rats Inbred Lew Female Collagen Swelling medicine.symptom Biomarkers medicine.drug |
| Zdroj: | Japanese Journal of Pharmacology. 78:225-228 |
| ISSN: | 0021-5198 |
| DOI: | 10.1254/jjp.78.225 |
| Popis: | This study demonstrated the decrease of bone mineral density (BMD) in the type II collagen (CII)-induced arthritis (CIA) model in rats and the relationship between BMD and paw edema and the effect of dexamethasone-21-phosphate (DEX). The paw swelling occurred on Day 10 and reached its peak on Day 18 after CII injection. BMD in the CII-injected group is lower than that in the control group. BMD in the proximal and distal regions of the femur largely decreased in comparison with that of the middle region. The oral administration of DEX (0.1 mg/kg) inhibited the swelling and decrease of BMD in all three regions of the femur. |
| Databáze: | OpenAIRE |
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