Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene

Autor:	Ruiz, A., Heilmann, S., Harold, D., Gerrish, A., Sims, R., Sotolongo-Grau, O., Espinosa, A., Alegret, M., Arrieta, J. L., Lacour, A., Leber, M., Becker, J., Becker, T., Lafuente, A., Ruiz, S., Vargas, L., Rodríguez, O., Ortega, G., Dominguez, M-A, IGAP, Mayeux, R., Haines, J. L., Pericak-Vance, M. A., Hernández, I., Farrer, L. A., Schellenberg, G. D., Chouraki, V., Launer, L. J., van Duijn, C., Seshadri, S., Antúnez, C., Breteler, Monique, Serrano-Ríos, M., Jessen, F., Wagner, H., Tárraga, L., Nöthen, M. M., Maier, W., Boada, M., Ramírez, A., Thelen, M., Mauleón, A., Rosende-Roca, M., Bellenguez, C., Bis, J. C., Breteler, M. M.
Přispěvatelé:	Epidemiology
Jazyk:	angličtina
Rok vydání:	2014
Předmět:	SNP thyroid receptor Genomics Locus (genetics) Single-nucleotide polymorphism Genome-wide association study genetics [Alzheimer Disease] TRIP4 protein human genetics [Genetic Loci] Biology Polymorphism Single Nucleotide molecular epidemiology Cellular and Molecular Neuroscience Alzheimer Disease dementia risk medicine GWAS Humans Genetic Predisposition to Disease ddc:610 Biological Psychiatry Genetics Odds ratio DNA genetics [Transcription Factors] medicine.disease R1 Psychiatry and Mental health Genetic Loci Spain Multiple comparisons problem genetics [Polymorphism Single Nucleotide] Original Article Alzheimer's disease Follow-Up Studies Genome-Wide Association Study Transcription Factors
Zdroj:	Translational Psychiatry 4(2), e358-e358 (2014). doi:10.1038/tp.2014.2 Translational Psychiatry Translational Psychiatry, 4. Nature Publishing Group
ISSN:	2158-3188
DOI:	10.1038/tp.2014.2
Popis:	To follow-up loci discovered by the International Genomics of Alzheimer's Disease Project, we attempted independent replication of 19 single nucleotide polymorphisms (SNPs) in a large Spanish sample (Fundacio ACE data set; 1808 patients and 2564 controls). Our results corroborate association with four SNPs located in the genes INPP5D, MEF2C, ZCWPW1 and FERMT2, respectively. Of these, ZCWPW1 was the only SNP to withstand correction for multiple testing (P = 0.000655). Furthermore, we identify TRIP4 (rs74615166) as a novel genome-wide significant locus for Alzheimer's disease risk (odds ratio = 1.31; confidence interval 95% (1.19-1.44); P = 9.74 x 10(-9)).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1693f7a0ab70ffc2307c4ebb0ddca9af Zobrazit plný text záznamu