Preoperative planar lymphoscintigraphy allows for sentinel lymph node detection in 51 dogs improving staging accuracy: Feasibility and pitfalls
| Autor: | Martina Manfredi, D. De Zani, Lavinia E. Chiti, Maurizio Longo, Mauro Di Giancamillo, Roberta Ferrari, Chiara Giudice, Damiano Stefanello, Vincenzina Pettinato, Donatella De Zani |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
040301 veterinary sciences Combined use Sentinel lymph node 030218 nuclear medicine & medical imaging 0403 veterinary science Tumor excision 03 medical and health sciences 0302 clinical medicine Dogs lymphoscintigraphy sentinel lymph node Nuclear Imaging Injection site medicine Animals Dog Diseases Lymph node Neoplasm Staging Original Investigation 99mTc General Veterinary business.industry Sentinel Lymph Node Biopsy 04 agricultural and veterinary sciences Gold standard (test) tumor staging medicine.anatomical_structure Median time Lymphatic Metastasis Feasibility Studies Radiology Lymph Nodes Radiopharmaceuticals business Gamma probe |
| Zdroj: | Veterinary Radiology & Ultrasound |
| ISSN: | 1740-8261 |
| Popis: | Sentinel lymph node (SLN) mapping is the current gold standard for the oncological staging of solid malignancies in humans. This prospective observational study describes the feasibility and the limits of preoperative lymphoscintigraphy for SLN detection in dogs with spontaneous malignancies and the improvements in staging accuracy. Client‐owned dogs with confirmed malignant neoplasia and absence of distant metastasis were prospectively enrolled. Lymphoscintigraphy was performed after the peritumoral injection of Technetium‐99m labeled nanocolloids. Regional dynamic and static images were acquired, with and without masking of the injection site with a lead shield. The dogs were then subjected to surgery for tumor excision and SLN extirpation. Intraoperative SLN detection was performed by combining methylene blue dye and a dedicated gamma probe. Overall, 51 dogs with a total of 60 solid malignant tumors were enrolled. Lymphoscintigraphy identified at least one SLN in 57 of 60 cases (95%). The SLN did not always correspond to the regional lymph node (35/57, 61.4%). The use of a lead shield, masking the injection site, markedly improved the SLN visibility. The median time of SLN appearance was 11.4 ± 9.3 min. No side effects were observed. Preoperative lymphoscintigraphy allows for SLN detection in dogs and can improve staging accuracy by either identifying the SLN in a different lymphosome than clinically expected or discriminating the draining node in uncertain cases. The combined use of preoperative and intraoperative techniques is recommended to increase the SLN detection rate. |
| Databáze: | OpenAIRE |
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