Allophagy: A macroautophagic process degrading spermatozoid-inherited organelles
| Autor: | Martin Sachse, Abderazak Djeddi, Vincent Galy, Sophie Louvet-Vallée, Connie Hajjar, Emmanuel Culetto, Lynn Boyd, Renaud Legouis, Sara Al Rawi |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Centriole Green Fluorescent Proteins Biology 03 medical and health sciences Mice Mitophagy Organelle medicine Autophagy Animals Caenorhabditis elegans Molecular Biology 030304 developmental biology Organelles 0303 health sciences Spermatozoon urogenital system Ubiquitin 030302 biochemistry & molecular biology Embryo Cell Biology Oocyte Spermatozoa Autophagic Punctum Cell biology medicine.anatomical_structure Cytoplasm |
| Popis: | In most animals, during oocyte fertilization the spermatozoon provides DNA and centrioles together with some cytoplasm and organelles, but paternal mitochondria are generally eliminated in the embryo. Using the model animal C. elegans we have shown that paternal organelle degradation is dependent on the formation of autophagosomes a few minutes after fertilization. This macroautophagic process is preceded by an active ubiquitination of some spermatozoon-inherited organelles. Analysis of fertilized mouse embryos suggests that this autophagy event is evolutionarily conserved. |
| Databáze: | OpenAIRE |
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