Performance of Digital PET Compared with High-Resolution Conventional PET in Patients with Cancer
| Autor: | Siert Knollema, Daniëlle Koopman, Jorn A. van Dalen, Henk Stevens, Pieter L. Jager, Cornelis H. Slump |
|---|---|
| Přispěvatelé: | Robotics and Mechatronics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male High resolution Cancer imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 Neoplasms Humans Medicine Radiology Nuclear Medicine and imaging In patient Prospective Studies Aged Neoplasm Staging Aged 80 and over Lesion detection business.industry 22/2 OA procedure Cancer Metabolic tumor volume Middle Aged medicine.disease Positron-Emission Tomography 030220 oncology & carcinogenesis Female business Nuclear medicine |
| Zdroj: | The Journal of nuclear medicine, 61(10), 1448-1454. Society of Nuclear Medicine Inc. |
| ISSN: | 0161-5505 |
| DOI: | 10.2967/jnumed.119.238105 |
| Popis: | Recently introduced PET systems using silicon photomultipliers with digital readout (dPET) have an improved timing and spatial resolution, aiming at a better image quality than conventional PET (cPET) systems. We prospectively evaluated the performance of a dPET system in patients with cancer, as compared with high-resolution (HR) cPET imaging. Methods: After a single 18F-FDG injection, 66 patients underwent dPET and cPET imaging in randomized order. We used HR reconstructions (2 × 2 × 2 mm voxels) for both scanners and determined SUVmax, SUVmean, lesion-to-background ratio (LBR), metabolic tumor volume (MTV), and lesion diameter in up to 5 18F-FDG-positive lesions per patient. Furthermore, we counted the number of visible and measurable lesions on each PET scan. Two nuclear medicine specialists determined, in a masked manner, the TNM score from both image sets in 30 patients referred for initial staging. For all 66 patients, these specialists separately evaluated image quality (4-point scale) and determined the scan preference. Results: We included 238 lesions that were visible and measurable on both PET scans. For 27 patients, we found 37 additional lesions on dPET (41%) that were unmeasurable (n = 14) or invisible (n = 23) on cPET. Mean (±SD) SUVmean, SUVmax, LBR, and MTV on cPET were 5.2 ± 3.9, 6.9 ± 5.6, 5.0 ± 3.6, and 2,991 ± 13,251 mm3, respectively. On dPET, SUVmean, SUVmax, and LBR increased by 24%, 23%, and 27%, respectively (P < 0.001) whereas MTV decreased by 13% (P < 0.001), compared with cPET. Visual analysis showed TNM upstaging with dPET in 13% of the patients (4/30). dPET images also had higher scores for quality (P = 0.003) and were visually preferred in most cases (65%). Conclusion: dPET improved the detection of small lesions, upstaged the disease, and produced images that were visually preferred to those from HR cPET. More studies are necessary to confirm the superior diagnostic performance of dPET.Keywords: digital PET; conventional PET; FDG PET; lesion detection; cancer imaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|