Positive result of Sars‐Cov‐2 in faeces and sputum from discharged patients with COVID‐19 in Yiwu, China
| Autor: | Xiaodong Zhang, Xiaoping Xia, Bin Li, Jian Xu, Yingping Wu, Junyu Li, Jianguo Wu, Yuanyuan Yu, Huina Tang, Yingying Hu, Youjiang Li |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Viral nucleic acid China medicine.medical_specialty discharge criteria Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) SARS‐CoV‐2 Feces Young Adult 03 medical and health sciences 0302 clinical medicine COVID‐19 Virology Internal medicine Humans Medicine 030212 general & internal medicine Research Articles Disease prognosis Aged SARS-CoV-2 business.industry Sputum COVID-19 Infant Middle Aged After discharge Patient Discharge Infectious Diseases Positive test result RNA Viral Female 030211 gastroenterology & hepatology medicine.symptom business virus nucleic acid test Research Article |
| Zdroj: | Journal of Medical Virology |
| ISSN: | 1096-9071 0146-6615 |
| DOI: | 10.1002/jmv.25905 |
| Popis: | Background With the effective prevention and control of COVID ‐ 19 in China, the number of cured cases increased significantly. Further monitoring of the disease prognosis and effective control of the "relapse" of the epidemic become the next focus of work. To analyse the clinical prognosis of discharged COVID‐19 patients by monitoring their SAR‐CoV‐2 nucleic acid status, which may provide evidence to establish discharge standards and follow‐up management for COVID‐19 patients. Methods We included 13 discharged COVID‐19 patients who were quarantined for 4‐week at home. The patient's daily clinical signs were recorded and sputum and faecal specimens were regularly sent for the detection of SARS‐CoV‐2 nucleic acid. Results The time between initial symptoms and meeting discharge criteria was 18 – 44 days with an average of 25 ± 6 days. The faecal samples of two patients still tested positive after meeting discharge criteria and the sputum samples of four patients returned positive 5 – 14 days after discharge. The rate of a recurring positive test result in samples from the respiratory system was 31%(4/13). Conclusion Under the present discharge criteria, the high presence of SARS‐CoV‐2 nucleic acid in faecal and respiratory samples of discharged COVID‐19 patients indicate potential infectivity. Therefore, we suggest that faecal virus nucleic acid should be tested as a routine monitoring index for COVID‐19 and a negative result be added to the criteria. Simultaneously, we should strengthen the regular follow‐up of discharged patients with continuous monitoring of the recurrence of viral nucleic acid. This article is protected by copyright. All rights reserved. |
| Databáze: | OpenAIRE |
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