Polymorphonuclear leukocyte random migration and chemotaxis in psoriatic and healthy adult smokers and non-smokers
| Autor: | P. Carrington, M.W. Greaves, T.S. Sonnex, P.G. Norris |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Palmoplantar pustulosis Adolescent Neutrophils chemical and pharmacologic phenomena Dermatology Random migration Pathogenesis In vivo Cell Movement Psoriasis Medicine Humans Aged Polymorphonuclear leukocyte business.industry Smoking hemic and immune systems Chemotaxis Middle Aged medicine.disease In vitro respiratory tract diseases Chemotaxis Leukocyte Immunology behavior and behavior mechanisms Female business circulatory and respiratory physiology |
| Zdroj: | The British journal of dermatology. 119(5) |
| ISSN: | 0007-0963 |
| Popis: | SUMMARY Random migration and chemotactic responsiveness of polymorphonuclear leukocytes (PMNs) from psoriatic and control smokers and non-smokers were studied in vitro and in vivo. In vivo, but not in vitro, PMNs from psoriatic smokers responded to a significantly greater degree to a standard chemotaxin than did PMNs from psoriatic non-smokers, control smokers and control non-smokers. This suggests that smoking has a selective effect on psoriatic PMNs. The possible relevance of this to the pathogenesis of psoriasis vulgaris and to palmoplantar pustulosis is discussed. |
| Databáze: | OpenAIRE |
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