RGS2 drives male aggression in mice via the serotonergic system
| Autor: | Annika Gesk, Stefan Herlitze, Jing Han, Katja Kösters, Takashi Maejima, Katharina Batzke, Claudia Janoschka, Patric Wollenweber, Evan S. Deneris, Melanie D. Mark |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Dorsal Raphe Nucleus Male Serotonin Adrenergic receptor Medicine (miscellaneous) Poison control Action Potentials Mice Transgenic Biology Anxiety Serotonergic General Biochemistry Genetics and Molecular Biology Article Receptors G-Protein-Coupled 03 medical and health sciences 0302 clinical medicine Dorsal raphe nucleus medicine Animals RNA Messenger lcsh:QH301-705.5 RGS2 Cells Cultured Aggression Depression Receptors Adrenergic Mice Inbred C57BL 030104 developmental biology lcsh:Biology (General) Hypothalamus Ventromedial Hypothalamic Nucleus Calcium medicine.symptom General Agricultural and Biological Sciences Neuroscience Immediate early gene Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery RGS Proteins Serotonergic Neurons |
| Zdroj: | Communications Biology Communications Biology, Vol 2, Iss 1, Pp 1-17 (2019) |
| ISSN: | 2399-3642 |
| Popis: | Aggressive behavior in our modern, civilized society is often counterproductive and destructive. Identifying specific proteins involved in the disease can serve as therapeutic targets for treating aggression. Here, we found that overexpression of RGS2 in explicitly serotonergic neurons augments male aggression in control mice and rescues male aggression in Rgs2−/− mice, while anxiety is not affected. The aggressive behavior is directly correlated to the immediate early gene c-fos induction in the dorsal raphe nuclei and ventrolateral part of the ventromedial nucleus hypothalamus, to an increase in spontaneous firing in serotonergic neurons and to a reduction in the modulatory action of Gi/o and Gq/11 coupled 5HT and adrenergic receptors in serotonergic neurons of Rgs2-expressing mice. Collectively, these findings specifically identify that RGS2 expression in serotonergic neurons is sufficient to drive male aggression in mice and as a potential therapeutic target for treating aggression. Melanie Mark et al demonstrate that RGS2, a protein associated with stress disorders, drives male aggression through the serotonergic system. They show that exogenous expression of RGS2 in serotogenic neurons augments aggression in male mice and rescues the docile phenotype of Rgs2 knockouts but does not affect anxiety. |
| Databáze: | OpenAIRE |
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