Basal-bolus therapy with insulin detemir using the 303 algorithm in the US PREDICTIVE 303 trial
| Autor: | Jean Louis Selam, Luigi F. Meneghini |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Blood Glucose
Male medicine.medical_treatment Self Administration Type 2 diabetes Drug Administration Schedule law.invention Insulin Detemir Randomized controlled trial law Diabetes mellitus Humans Insulin Medicine Pharmacology (medical) Physician's Role Aged Insulin detemir Glycated Hemoglobin business.industry Blood Glucose Self-Monitoring Body Weight Basal bolus General Medicine Middle Aged medicine.disease United States Insulin Long-Acting Clinical trial Treatment Outcome Diabetes Mellitus Type 2 Multicenter study Practice Guidelines as Topic Linear Models Female Drug Monitoring Safety business Algorithm Algorithms medicine.drug |
| Zdroj: | Advances in Therapy. 26:194-207 |
| ISSN: | 1865-8652 0741-238X |
| Popis: | The aim of this study was to compare a simplified patient-driven algorithm (303 Algorithm) to physician-driven adjustments in a subset of 193 patients with type 2 diabetes from the PREDICTIVE 303 study who were using basal-bolus insulin therapy.PREDICTIVE 303 was a 26-week, randomized, phase 4 study, in which subjects were either instructed to adjust their insulin detemir dose every 3 days by +/-3 units if mean fasting plasma glucose (FPG) values were above 110 mg/dL or below 80 mg/dL (303 Algorithm), or had physicians adjust the insulin detemir dose according to usual practice (Standard-of-care).Patients in both groups achieved similar reductions in glycated hemoglobin (-0.2% and -0.3% for 303 Algorithm and Standard-of care groups, respectively; between groups P=0.60). 303 Algorithm group patients achieved a greater reduction in FPG (-21.3 mg/dL vs. 0.2 mg/dL; between groups P=0.03). Both 303 Algorithm and Standard-of care groups experienced a similar rate of overall hypoglycemia, and similar weight reduction (-1.7 kg and -0.4 kg, respectively; between groups P=0.07). Over 82% of patients in both groups used insulin detemir once daily.Adjustments of a once-daily detemir dose by patients using the 303 Algorithm in a basal-bolus setting is equally effective in improving glycemic control in patients with type 2 diabetes compared with physician-directed basal dose adjustments. |
| Databáze: | OpenAIRE |
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