The fate of I-131-labeled human growth hormone in the rabbit
| Autor: | Mary Kendall Parker, Seymour Reichlin, Robert D. Utiger, Salmon Salmon |
|---|---|
| Rok vydání: | 1962 |
| Předmět: |
medicine.medical_specialty
Kidney biology Human Growth Hormone Serum albumin Skeletal muscle Spleen Human serum albumin chemistry.chemical_compound Somatropin Endocrinology medicine.anatomical_structure chemistry Internal medicine Growth Hormone medicine biology.protein Animals Humans Rabbits Trichloroacetic acid Pancreas medicine.drug |
| Zdroj: | Endocrinology. 70 |
| ISSN: | 0013-7227 |
| Popis: | The rate of disappearance from plasma and tissue localization of radioactivity were determined in rabbits following intravenous injections of radioiodinated human growth hormone (HGH*), and radioiodinated human serum albumin (HSA*). Tissue localization of radioactivity after Nal131 injection was also examined. HGH* was quickly cleared from the blood; during the extremely rapid initial period (between 2 and 10 minutes), the concentration of trichloroacetic acid precipitable plasma radioactivity fell by 61 %. For the interval 10 to 60 minutes, mean half-time of disappearance of 17.6 ±1.8 minutes (standard error) was determined in a group of 11 rabbits. Half-time of disappearance did not differ in young as compared with old animals. Listed in decreasing order, the tissue radioactivity concentrations at 90 minutes were: kidney, liver, lung, spleen, skin, adrenal, testis, intestine, marrow, pancreas, skeletal muscle fat and cerebral cortex. Substantial proportions of the radioactivity found in the liver and ki... |
| Databáze: | OpenAIRE |
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