Effect of restoration of euthyroidism on visfatin concentrations and body composition in women
| Autor: | Agata Czarnywojtek, Marek Ruchała, Michal Kloska, Nadia Sawicka-Gutaj, Paulina Ziółkowska, Dorota Mańkowska-Wierzbicka, Jerzy Sowiński, Ariadna Zybek-Kocik |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
endocrine system Hashimoto's disease endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Graves' disease Adipose tissue 030209 endocrinology & metabolism Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences pre-B-cell colony enhancing factor 0302 clinical medicine Endocrinology Insulin resistance Weight loss Internal medicine visfatin Internal Medicine medicine Hashimoto’s disease business.industry Insulin Research medicine.disease RC648-665 Trunk nicotinamide phosphoribosyltransferase 030220 oncology & carcinogenesis fat tissue Thyroid function medicine.symptom business Graves’ disease |
| Zdroj: | Endocrine Connections Endocrine Connections, Vol 10, Iss 4, Pp 462-470 (2021) |
| ISSN: | 2049-3614 |
| Popis: | Dysregulation of thyroid function has known impact on body metabolism, however, data regarding metabolic outcome after restoration of thyroid function is limited. Therefore, the aim of the study was to investigate the effect of restoration of euthyroidism on serum visfatin, and its associations with insulin resistance and body composition. This is an observational study with consecutive enrollment. Forty-nine hyperthyroid (median age of 34 years) and 44 hypothyroid women (median age of 46 years) completed the study. Laboratory parameters and body composition analysis were assessed before and after the therapy. In the hyperthyroid group, visfatin concentrations increased ( P < 0.0001), while glucose concentrations decreased ( P < 0.0001). Total body mass and fat mass in the trunk and limbs significantly increased during the treatment. In the hypothyroid group, significant weight loss resulted from decrease of fat and muscle masses in trunk and limbs. Visfatin serum concentrations positively correlated with total fat mass ( r = 0.19, P = 0.01) and insulin concentrations ( r = 0.17, P = 0.018). In conclusion, restoration of thyroid function is not associated with beneficial changes in body composition, especially among hyperthyroid females. |
| Databáze: | OpenAIRE |
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