Network determinants of cardiovascular calcification and repositioned drug treatments

Autor:	Rui-Sheng Wang, Joseph Loscalzo, Jane A. Leopold, Jun Seop Song
Rok vydání:	2020
Předmět:	0301 basic medicine Myocytes Smooth Muscle Bioinformatics Biochemistry Muscle Smooth Vascular calcification 03 medical and health sciences 0302 clinical medicine Cardiovascular calcification blood vessel Fibrosis therapeutics Genetics medicine Humans protein interaction Vascular Calcification Molecular Biology Research Articles smooth muscle cell Cells Cultured Inflammation Everolimus business.industry Calcinosis Thrombosis medicine.disease Pomalidomide Coronary Vessels Temsirolimus Drug repositioning 030104 developmental biology medicine.anatomical_structure Pharmaceutical Preparations business 030217 neurology & neurosurgery Research Article Biotechnology medicine.drug Blood vessel Calcification
Zdroj:	The FASEB Journal
ISSN:	1530-6860
Popis:	Ectopic cardiovascular calcification is a highly prevalent pathology for which there are no effective novel or repurposed pharmacotherapeutics to prevent disease progression. We created a human calcification endophenotype module (ie, the “calcificasome”) by mapping vascular calcification genes (proteins) to the human vascular smooth muscle‐specific protein‐protein interactome (218 nodes and 632 edges, P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16838c7b211c915778e5e222612ae5c2 https://pubmed.ncbi.nlm.nih.gov/32638415 Zobrazit plný text záznamu Plný text