Simultaneous detection of sibutramine and phenolphthalein in a diet jelly health food product that caused health problems

Autor: Tomohide Fukiwake, Sachiyo Oosawa, Hiroki Yoshino, Tatsuya Shinozuka, Maki Nishimura, Rie Ito, Hiroshi Akiyama
Rok vydání: 2022
Předmět:
Zdroj: Analytical Sciences. 39:455-461
ISSN: 1348-2246
0910-6340
DOI: 10.1007/s44211-022-00217-0
Popis: The Public Health Center in Chiba Prefecture, Japan, received a consultation from a resident of Chiba Prefecture who consumed a diet jelly health food product and experienced health problems. To investigate the cause of the health problems, we examined the two food products for the presence of pharmaceutical ingredients. A screening analysis using ultra-high-performance liquid chromatography with a photodiode array detector (UPLC-PDA) indicated the presence of sibutramine and phenolphthalein in the food product. Analysis using an ultra-high-performance liquid chromatography-quadrupole-Kingdon trap mass spectrometer (UHPLC-Q-Kingdon trap MS) confirmed the presence of sibutramine and phenolphthalein. Quantitative analysis using UPLC-PDA showed that sibutramine and phenolphthalein were present at 15 and 16 mg/bag and 2.4 and 2.6 mg/bag, respectively. According to the drug insert for sibutramine capsules in the United States, the recommended medicinal dose of sibutramine should not exceed 15 mg/day, and the amount ingested in the present case exceeded that value. The present study results indicated that ingestion of the jelly health food product may cause health problems.
Databáze: OpenAIRE
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