Decreased Count and Dysfunction of Circulating EPCs in Postmenopausal Hypercholesterolemic Females via Reducing NO Production
| Autor: | Wan-Zhou Wu, Quan-Neng Yan, Fanyan Luo, Ying Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:Internal medicine medicine.medical_specialty Article Subject Endothelial repair Endogeny 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine In patient No production Endothelial dysfunction Progenitor cell lcsh:RC31-1245 Molecular Biology Therapeutic strategy business.industry Cell Biology medicine.disease 030104 developmental biology Endocrinology embryonic structures cardiovascular system Cardiovascular Injury business Research Article circulatory and respiratory physiology |
| Zdroj: | Stem Cells International Stem Cells International, Vol 2018 (2018) |
| ISSN: | 1687-966X |
| DOI: | 10.1155/2018/2543847 |
| Popis: | Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown. Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia. No significant differences were found between postmenopausal females and age-matched males. NO production showed positive correlation with the activity and count of circulating EPCs in patients with hypercholesterolemia. Flow-mediated dilatation (FMD) is directly interrelated with EPC counts and function. Our findings reveal that decreased EPC count and endothelial dysfunction lead to less NO production in hypercholesterolemic postmenopausal females. Maintaining the EPC numbers and activity might be emerging as a potential therapeutic strategy to reduce the risk of cardiovascular injury in elder women. |
| Databáze: | OpenAIRE |
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