Dose-response decrease in plasma tryptophan and in brain tryptophan and serotonin after tryptophan-free amino acid mixtures in rats
| Autor: | Odoardo Tofanetti, Piervitto Cipolla, Egidio A. Moja, Daniele Castoldi |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Plasma tryptophan Biology High-performance liquid chromatography General Biochemistry Genetics and Molecular Biology Acetic acid chemistry.chemical_compound Internal medicine Blood plasma medicine Animals Amino Acids General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Chromatography Tryptophan Brain Rats Inbred Strains General Medicine Hydroxyindoleacetic Acid Rats Amino acid Endocrinology chemistry Tryptophan.free |
| Zdroj: | Life Sciences. 44:971-976 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(89)90497-9 |
| Popis: | Rats fasted 15 hours were treated p.o. with increasing amounts (660 and 1320 mg/kg body weight) of a mixture containing a fixed proportion of seven essential amino acids (L-phenylalanine 13.6%, L-leucine 6.0%, L-isoleucine 12.1%, L-methionine 12.1%, L-lysine 30.3%, L-threonine 10.6%, L-valine 15.2%) and lacking tryptophan. The mixtures produced a dose-response decrease of free (by 34% after the lower dose and by 58% after the higher dose of the mixture) and total (by 10 and 31%) plasma tryptophan and of brain tryptophan (by 38 and 65%), serotonin (by 17 and 41%) and 5-hydroxyindole acetic acid (by 21 and 49%). The mechanisms of these changes are discussed. |
| Databáze: | OpenAIRE |
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