Effects of long-term treatment for obstructive sleep apnea on pulse wave velocity
| Autor: | Masahiro Yasutake, Tsunenori Saito, Kyoichi Mizuno, Shigeyuki Sugiyama, Kuniya Asai, Tsunehiro Saito |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Sympathetic Nervous System Time Factors Physiology medicine.medical_treatment Blood Pressure Heart Rate Internal medicine Heart rate Internal Medicine medicine Humans Continuous positive airway pressure Pulse wave velocity Sleep Apnea Obstructive Continuous Positive Airway Pressure business.industry Sleep apnea Middle Aged medicine.disease respiratory tract diseases Obstructive sleep apnea Treatment Outcome Blood pressure Pulsatile Flow Anesthesia Hypertension Cardiology Arterial stiffness Cardiology and Cardiovascular Medicine business Body mass index Blood Flow Velocity Follow-Up Studies circulatory and respiratory physiology |
| Zdroj: | Hypertension Research. 33:844-849 |
| ISSN: | 1348-4214 0916-9636 |
| DOI: | 10.1038/hr.2010.77 |
| Popis: | Continuous positive airway pressure (CPAP) treatment improves endothelial function and sympathetic activity in patients with obstructive sleep apnea (OSA). However, the long-term effects of CPAP on pulse wave velocity (PWV), which reflects arterial stiffness that is associated with cardiovascular events, have not been evaluated in OSA patients with or without hypertension (HT). In this study, 212 male OSA patients who had been receiving CPAP treatment for 2 years and were divided into two groups, those with HT (n=114) and those without (n=98), were studied. In both HT and normotensive (NT) patients, PWV decreased significantly over the first 6 months of treatment (P=0.005 and 0.010, respectively), before increasing gradually from 6 to 24 months. Body mass index (BMI), body weight, heart rate (HR), systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels decreased significantly in the HT group over the 2 years of CPAP treatment (P |
| Databáze: | OpenAIRE |
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