Dioxatrine, a potent and specific rumenal ulcer-preventing agent in rats

Autor:	C. J. E. Niemegeers, P. A. J. Janssen
Rok vydání:	1964
Předmět:	Atropine Pharmacology Mydriatics Peptic Ulcer Tertiary amine business.industry Research Free access Parasympatholytics Pharmaceutical Science Rats Glucose Piperidines Oral administration Mydriatic Effects Medicine business Ulcer Atropine sulphate medicine.drug
Zdroj:	Journal of Pharmacy and Pharmacology. 16:26-32
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1964.tb07372.x
Popis:	When rats are starved with free access to a 20% glucose solution, extensive rumenal ulcers are found in almost all animals at the end of the third week. The formation of these ulcers may be inhibited by dissolving adequate amounts of two anti-acetylcholine agents in the glucose solution. A minimum of about 8 mg/kg of atropine sulphate daily is required for significant activity. Submaximal mydriatic effects are observed after oral administration of this dose. Dioxatrine, a tertiary amine of novel structure, inhibited ulcer formation at dose levels devoid of significant mydriatic activity. Dioxatrine prevents experimental ulcers in rats in one twentieth the dose of atropine.
Databáze:	OpenAIRE
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