A Randomized, Controlled Pilot Trial Comparing Platelet-Rich Plasma to Topical Minoxidil Foam for Treatment of Androgenic Alopecia in Women
| Autor: | Michael G. Heckman, Jennifer R. Arthurs, Cheryl M. Desmond, Thais P. Pincelli, Shane A. Shapiro, Charles J. Bruce, Nancy N. Diehl, Alison J. Bruce, Erika J. Douglass |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Administration Topical education Treatment outcome Pilot Projects Dermatology law.invention 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method law Medicine Humans reproductive and urinary physiology Topical minoxidil Aerosols Cross-Over Studies integumentary system business.industry Platelet-Rich Plasma Pilot trial Alopecia General Medicine Middle Aged Crossover study female genital diseases and pregnancy complications body regions Clinical trial Treatment Outcome Patient Satisfaction 030220 oncology & carcinogenesis Platelet-rich plasma Minoxidil Quality of Life Surgery Female Hair loss disorder business |
| Zdroj: | Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 46(6) |
| ISSN: | 1524-4725 |
| Popis: | Androgenic alopecia (AGA) is a common hair loss disorder. Studies have demonstrated successful treatment with platelet-rich plasma (PRP) in men, but studies in women are few.To evaluate PRP in the treatment of AGA in women, compared with topical minoxidil.Twenty women with AGA received topical minoxidil for 12 weeks and injectable PRP for 12 weeks in a randomized crossover design with an 8-week washout between treatments. Standardized TrichoScan analysis and quality-of-life questionnaires were assessed at baseline and 12-week follow-up for each treatment.After PRP, significant increases from baseline to Week 12 in TrichoScan analysis hair count (p = .002) and vellus hair density (p = .009) occurred. However, minoxidil resulted in significant increases in hair count (p.001), vellus hair density (p = .03), terminal hair density (p = .004), and cumulative thickness (p = .004). Several quality of life responses improved from baseline to Week 12 after PRP treatment, whereas no improvements were noted after minoxidil.Platelet-rich plasma is an effective treatment for hair regrowth in female AGA, although not as effective as minoxidil. However, the improved quality of life responses after PRP, but not minoxidil, suggest a potential overall greater degree of satisfaction with PRP.I.NCT03488108. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|